Copper‐Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α‐Bromoamides
Xueling Mo, Bin Chen, Guozhu Zhang
Abstract
An asymmetric copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species .
Topics & Concepts
Sonogashira couplingEnantioselective synthesisCopperCatalysisCombinatorial chemistryType (biology)ChemistryOrganic chemistryPalladiumBiologyEcologyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions