Ring Expansion to 6‐, 7‐, and 8‐Membered Benzosilacycles through Strain‐Release Silicon‐Based Cross‐Coupling
Ying Qin, Jie‐Lian Han, Cheng‐Wei Ju, Dongbing Zhao
Abstract
The synthesis of silacycles is highly appealing due to their important applications in organic synthesis, medicinal chemistry, and materials chemistry. However, sila-tetralins and sila-benzosuberanes are surprisingly under-represented due to a lack of general methods to access these compounds. We successfully developed a Pd-catalyzed strain-release silicon-based cross-coupling as an unprecedented ring-expansion method, which constitutes a general route for preparing diverse sila-tetralins and sila-benzosuberanes.
Topics & Concepts
Strain (injury)Ring (chemistry)SiliconCoupling (piping)Materials scienceComposite materialChemistryOptoelectronicsOrganic chemistryBiologyAnatomyOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsOrganometallic Complex Synthesis and Catalysis