Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada)
Thierry Comlan Marc Medehouenou, Cynthia Roy, Pierre-Yves Tremblay, Audray St-Jean, Salma Meziou, Gina Muckle, Pierre Ayotte, Michel Lucas
Abstract
) was statistically associated with an increment of 0.21 (95% CI: 0.08, 0.33) for valine, 0.15 (95% CI: 0.02, 0.27) for isoleucine and 0.17 (95% CI: 0.04, 0.29) for tyrosine. Insulin concentration increased with concentrations of all amino acids (P < 0.05) except methionine. None of the acylcarnitines measured were statistically significantly associated with adiposity or T2D biomarkers A signature of metabolites, particularly higher levels of branched-chain amino acids, might allow for early detection of T2D among school-aged Inuit children.
Topics & Concepts
ValineAdiponectinOverweightEndocrinologyInternal medicineMetaboliteMedicineObesityType 2 diabetesLeptinGlucose homeostasisAmino acidDiabetes mellitusChemistryInsulin resistanceBiochemistryDiet and metabolism studiesNutritional Studies and DietIndigenous Studies and Ecology