Mechanisms of nitric oxide in spinal cord injury
Jiahui Hao, Ye Yang, Guoguo Zhang, Haitao Shen, Jinquan Li, Gang Chen
Abstract
Spinal cord injury (SCI) is a primary lesion of the spinal cord that results from external forces or diseases, accompanied by a cascade of secondary events. Nitric oxide, an endogenous gas that functions as a signaling molecule in the human body, plays a crucial role in vasodilation of smooth muscles, regulation of blood flow and pressure, and inflammatory response. This article provides a comprehensive overview of the involvement of nitric oxide in SCI and highlights recent advances in basic research on pharmacological agents that inhibit nitric oxide elevation after SCI, offering valuable insights for future therapeutic interventions targeting SCI.
Topics & Concepts
Nitric oxideSpinal cord injuryMedicineSpinal cordLesionNeuroscienceEndogenyPathophysiologyAnesthesiaPharmacologyPathologyInternal medicinePsychologyPsychiatrySpinal Cord Injury ResearchNitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion