Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl<sub>2</sub>-induced Polyploid Giant Cancer Cells
Minying Zheng, Lankai Chen, Junjie Fu, Xiaohui Yang, Shuo Chen, Wenzheng Fu, Yuwei Li, Shiwu Zhang
Abstract
-induced overexpression of Cdc42 plays a critical role in increasing the infiltration and migration abilities of PGCCs and progeny cells by regulating cytoskeleton protein expression.
Topics & Concepts
CDC42BiologyStathminCell biologyCancer cellCytoskeletonTransfectionCell cycleMicrotubulePseudopodiaCellMolecular biologyCell cultureActinCancerGeneticsMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysUbiquitin and proteasome pathways