Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation
Li Zhou, Wen-Ming Chen, Chenyang Cao, Yonghui Shi, Wenchong Ye, Jiliang Hu, Lingli Wang, Wen Zhou
Topics & Concepts
CYP1B1DU145ChemistryDrug resistancePharmacologyCytochrome P450DocetaxelDrugCancer cellBiochemistryCancerBiologyEnzymeGeneticsLNCaPProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors Research