iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology
Yanyan Peng, Benjamin Liou, Yi Lin, Christopher N. Mayhew, Sheila M. Fleming, Ying Sun
Abstract
-associated PD.
Topics & Concepts
NeuropathologyNeurodegenerationNeural stem cellSubstantia nigraBiologyNeuroinflammationAlpha-synucleinCell biologyChemistryCancer researchStem cellParkinson's diseaseImmunologyPathologyMedicineDiseaseInflammationLysosomal Storage Disorders ResearchCellular transport and secretionRetinal Development and Disorders