Increased Dose to Organs in Urinary Tract Associates With Measures of Genitourinary Toxicity in Pooled Voxel-Based Analysis of 3 Randomized Phase III Trials
Marco Marcello, James W. Denham, Angel Kennedy, Annette Haworth, Allison Steigler, Peter B. Greer, Lois Holloway, Jason Dowling, Michael Jameson, Dale Roach, David Joseph, S. Gulliford, David P. Dearnaley, Matthew R. Sydes, Emma Hall, Martin A. Ebert
Abstract
Anatomically-localized dose-toxicity relationships were determined for late genitourinary symptoms in the urethra and urinary sphincters. Low-intermediate doses to the extraprostatic urethra were associated with risk of late dysuria and haematuria, while dose to the urinary sphincters was associated with incontinence.
Topics & Concepts
Genitourinary systemDysuriaMedicineUrologyUrethraUrethral sphincterUrinary systemVoxelNuclear medicineRadiologyInternal medicineAdvanced Radiotherapy TechniquesRadiation Dose and ImagingRadiomics and Machine Learning in Medical Imaging