Release Kinetics of Dexamethasone Phosphate from Porous Chitosan: Comparison of Aerogels and Cryogels
Coraline Chartier, Sytze Buwalda, Blessing C. Ilochonwu, Hélène Van Den Berghe, Audrey Béthry, Tina Vermonden, Martina Viola, Benjamin Nottelet, Tatiana Budtova
Abstract
Porous chitosan materials as potential wound dressings were prepared via dissolution of chitosan, nonsolvent-induced phase separation in NaOH–water, formation of a hydrogel, and either freeze-drying or supercritical CO 2 drying, leading to “cryogels” and “aerogels”, respectively. The hydrophilic drug dexamethasone sodium phosphate was loaded by impregnation of chitosan hydrogel, and the release from cryogel or aerogel was monitored at two pH values relevant for wound healing. The goal was to compare the drug-loading efficiency and release behavior from aerogels and cryogels as a function of the drying method, the materials’ physicochemical properties (density, morphology), and the pH of the release medium. Cryogels exhibited a higher loading efficiency and a faster release in comparison with aerogels. A higher sample density and lower pH value of the release medium resulted in a more sustained release in the case of aerogels. In contrast, for cryogels, the density and pH of the release medium did not noticeably influence release kinetics. The Korsmeyer–Peppas model showed the best fit to describe the release from the porous chitosan materials into the different media.