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Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results

Christine D. Palmer, Amy Rappaport, Matthew J. Davis, Meghan G. Hart, Ciaran D. Scallan, Sue‐Jean Hong, Leonid Gitlin, Lauren D. Kraemer, Sonia Kounlavouth, Aaron Yang, Lindsey Smith, Desiree Schenk, Mojca Škoberne, Kiara Taquechel, Martina Marrali, Jason R. Jaroslavsky, Charmaine N. Nganje, Elizabeth Maloney, Rita Zhou, Daniel Navarro-Gomez, Adrienne C. Greene, Gijsbert M. Grotenbreg, Renee L. Greer, Wade Blair, Minh Duc Cao, Shawn Chan, Kyounghwa Bae, Alexander I. Spira, Sameek Roychowdhury, David P. Carbone, Brian S. Henick, Charles G. Drake, Benjamin Solomon, Daniel H. Ahn, Amit Mahipal, Steve Maron, Benny Johnson, Raphaël F. Rousseau, Roman Yelensky, Chih‐Yi Liao, Daniel V.T. Catenacci, Andrew M. Allen, Andrew R. Ferguson, Karin Jooss

2022Nature Medicine226 citationsDOIOpen Access PDF

Topics & Concepts

MedicineOncologyInternal medicineAdverse effectIpilimumabNivolumabTolerabilityCancer vaccineClinical endpointImmunologyCancerImmunotherapyClinical trialImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersCAR-T cell therapy research
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results | Litcius