Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond
Andrew L. O’Brien, Julie M. West, Tiam M. Saffari, Minh Khanh Nguyen, Amy M. Moore
Abstract
Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the central nervous system, peripheral nerves have the ability to regenerate lost axons after injury; however, axonal regeneration does not equate to full restoration of function. To overcome this physiological shortcoming, advances in nerve regeneration and repair are paramount, including electrical stimulation, gene therapy, and surgical technique advancements.
Topics & Concepts
Regeneration (biology)StimulationNeurosciencePeripheral nervous systemPeripheral nerveNerve repairMedicinePeripheral nerve injuryGenetic enhancementNerve injuryBiologyCentral nervous systemAnatomyGeneCell biologyBiochemistryNerve Injury and RehabilitationNerve injury and regenerationSpinal Cord Injury Research