Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route
Sveva Pelliccia, Carmen Cerchia, Francesca Esposito, Rolando Cannalire, Angela Corona, Elisa Costanzi, Maria Kuzikov, Philip Gribbon, Andrea Zaliani, Margherita Brindisi, Paola Storici, Enzo Tramontano, Vincenzo Summa
Topics & Concepts
ChemistryStereochemistryProteaseMoietyStructure–activity relationshipEnzymeCombinatorial chemistryBiochemistryIn vitroComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchRNA and protein synthesis mechanisms