Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling
Pavla Boháčová, Marina Terekhova, Petr Tsurinov, Riley Mullins, Kamila Husarcikova, Irina Shchukina, Alina Ulezko Antonova, Barbora Echalar, Jan Kössl, Adam Saidu, Thomas Francis, Chelsea Mannie, Laura Arthur, Stephen D. R. Harridge, Daniel Kreisel, Philip A. Mudd, Angela M. Taylor, Coleen A. McNamara, Marina Cella, Sidharth V. Puram, Theo van den Broek, Femke van Wijk, Pirooz Eghtesady, Maxim N. Artyomov
Abstract
cells. Identification of RTEs enables direct assessment of thymic health. Furthermore, resolving the dynamics of naive T cell remodeling yields insight into vaccination and infection responsiveness throughout aging.
Topics & Concepts
BiologyCD38Profiling (computer programming)Cell biologyImmunologyStem cellCD34Operating systemComputer scienceImmune Cell Function and InteractionT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research