Upholding hyaluronic acid's multi-functionality for nucleic acid drug delivery to target EMT in breast cancer
Lorenz Isert, Irene Gialdini, Thi My Hanh Ngo, Gabriele Loiudice, Don C. Lamb, Olivia M. Merkel
Abstract
CD44-HA mediated endocytosis. Finally, our results indicate different internalization kinetics and efficiencies between CD44v and CD44s isotypes, highlighting the need to consider CD44 heterogeneities in the clinical development of HA-based drug delivery systems.
Topics & Concepts
Hyaluronic acidNucleic acidDrug deliveryDrugBreast cancerCancerChemistryNanotechnologyCancer researchCombinatorial chemistryPharmacologyBiochemistryMedicineMaterials scienceInternal medicineAnatomyRNA Interference and Gene DeliveryBiopolymer Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques