A Concise Review of Organoid Tissue Engineering: Regenerative Applications and Precision Medicine
Karnika Yogeswari Makesh, Abilash Navaneethan, Mrithika Ajay, Ganesh Munuswamy‐Ramanujam, Arulvasu Chinnasamy, Dhanavathy Gnanasampanthapandian, Kanagaraj Palaniyandi
Abstract
Organoids are three-dimensional tissue culture models derived from stem cells, and they have become one of the most valuable tools in biomedical research. These self-organizing miniature organs mimic the structure−function properties of their in vivo counterparts and offer an exceptional prospective for disease modeling, drug discovery, and regenerative medicine. By replicating the complexity of human tissue, organoids enable the study of disease pathophysiology, tissue development, and cellular interactions in a highly controlled and manipulable environment. Recent developments in organoid technology have enabled the production of functional organoids of various tissues. These systems have proven to be highly promising tools for personalized medicine. In addition, organoids have also raised hopes for the development of functional transplantable organs, transforming the study of regenerative medicine. This review provides an overview of the current state of organoid technology and its application and prospects and focuses on the transformative impact of organoid technology on biomedical research and its contribution to human health.