Lipid nanoparticles-loaded with toxin mRNA represents a new strategy for the treatment of solid tumors
Yasmin Granot-Matok, Assaf Ezra, Srinivas Ramishetti, Preeti Sharma, Gonna Somu Naidu, Itai Benhar, Dan Peer
Abstract
We propose mmRNA-loaded LNPs as a new class of anti-tumoral, toxin-based therapy.
Topics & Concepts
ImmunotoxinNanocarriersMessenger RNACytotoxicityImmune systemGenetic enhancementCancerCancer researchCancer cellGene deliveryToxinChemistryMedicineBiologyGenePharmacologyImmunologyMicrobiologyIn vitroBiochemistryInternal medicineDrugToxin Mechanisms and ImmunotoxinsBacteriophages and microbial interactionsCancer Research and Treatments