Discovery of novel pyridazinone derivatives as EGFRWT/ EGFRT790M kinase inhibitors; design, synthesis, antitumor evaluation, and molecular dynamic simulations
Sara Y Ewieda, Eman M. Ahmed, Peter A. Halim, Shaymaa G. Ibrahim, Khaled M. Gouda, Mohnad Abdalla, Wafa Ali Eltayb, Mohamed T.M. Nemr
Topics & Concepts
ChemistrySorafenibDoxorubicinKinaseErlotinibCell cycle checkpointDocking (animal)Cytotoxic T cellCell growthCell cycleStereochemistryCytotoxicityLead compoundCell cultureApoptosisMolecular modelStructure–activity relationshipCancer cellBiochemistryCellPharmacologyPeptideSelectivityCombinatorial chemistryMolecular dynamicsPharmacophoreAzoleBinding siteCancer researchEnzymeDerivative (finance)EGFR inhibitorsActive siteSynthesis and biological activityColorectal Cancer Treatments and StudiesCancer therapeutics and mechanisms