Activation of Ethanol via Conjunction of a Photocatalyst and a HAT Reagent for the Synthesis of Benzimidazoles
Saloni Kumari, Abhisek Joshi, Ishani Borthakur, Sabuj Kundu
Abstract
The transformation of ethanol to value-added chemicals has tremendous potential. However, generally, harsh reaction conditions are needed for the functionalization of ethanol due to its high dehydrogenation energy. Herein, a metal-free photo-mediated activation of challenging ethanol and higher aliphatic alcohols for the synthesis of differently functionalized benzimidazoles under mild conditions is disclosed. The interplay of a photocatalyst and a HAT reagent facilitated the activation of aliphatic alcohols. A wide array of diamines with different functional groups were well tolerated, and the protocol was also extended to N -substituted diamines for the synthesis of industrially important benzimidazoles. A probable catalytic cycle was proposed based on various mechanistic studies.