Zinc-catalyzed asymmetric [3 + 2] annulations for the construction of chiral spiro[1-indanone-γ-butyrolactones] <i>via</i> a C–N bond cleavage process
Jiaojiao Han, Cui Zhang, Guang‐Jian Mei, Yuan‐Zhao Hua, Shi‐Kun Jia, Min‐Can Wang
Abstract
This is an efficient asymmetric Michael/lactonization cascade reaction via a Brønsted base and Lewis acid cooperative activation model.
Topics & Concepts
ChemistryCatalysisCleavage (geology)ZincBond cleavageMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryGeotechnical engineeringEngineeringFracture (geology)Asymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods