Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review
Maham Farshidpour, Monjur Ahmed∥, Shilpa Junna, Juanita L. Merchant
Abstract
Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
Topics & Concepts
MedicineMyeloid-derived Suppressor CellSuppressorCancer researchImmune systemTumor microenvironmentImmunologyMyeloid cellsMetastasisMyeloidCancerInternal medicineImmune cells in cancerInflammatory Biomarkers in Disease PrognosisChemokine receptors and signaling