Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury
Jingyao Song, Bin Fan, Lin Che, Yi-Ran Pan, Si‐Ming Zhang, Ying Wang, Victoria I. Bunik, Guangyu Li
Abstract
experiments verified neuroprotection via inhibiting ER stress-related autophagy in light-damaged retinas of mice. In conclusion, the above results suggest that light-induced photo-oxidative stress may trigger subsequent activation of ER stress and prolonged autophagy in photoreceptors and RPE cells. Suppressing ER stress may abrogate over-activated autophagy and protect the retina against light injury.
Topics & Concepts
Endoplasmic reticulumAutophagyCell biologyStress (linguistics)RetinalChemistryBiologyMedicineOphthalmologyApoptosisBiochemistryPhilosophyLinguisticsAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseMosquito-borne diseases and control