A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics
Lihua Li, Zefeng Lin, Xingyi Xu, Wanshun Wang, Hu Chen, Zhibin Feng, Zhongmin Yang, Jianhua Hao
Abstract
Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth–manganese core–shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO x, was designed for 4T1 tumor theranostics in vitro and in vivo . The BDS-GOx@MnO x nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO x nanozymes have also been systematically studied and revealed.