Combination of DNA demethylation and chemotherapy to trigger cell pyroptosis for inhalation treatment of lung cancer
Beibei Xie, Tingting Liu, Shuang Chen, Yan Zhang, Dongxian He, Qian Shao, Zhen Zhang, Chenhui Wang
Abstract
Inhaled PLGA porous microspheres loaded with Decitabine (DAC) and Doxorubicin (DOX) were prepared to induce cell pyroptosis for orthotopic lung cancer therapy with fewer systemic side effects.
Topics & Concepts
PyroptosisCancer researchDoxorubicinApoptosisImmune systemInflammationGene silencingLung cancerCellChemistryProgrammed cell deathPharmacologyMedicineChemotherapyImmunologyPathologyInternal medicineBiochemistryGeneInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideCancer Immunotherapy and Biomarkers