Molecular Mechanism of L-Pyroglutamic Acid Interaction with the Human Sour Receptor
Sanung Eom, Shinhui Lee, Jiwon Lee, Minsu Pyeon, Hye Duck Yeom, Jung Hee Song, Eun Ji Choi, Moeun Lee, Junho H Lee, Ji Yoon Chang
Abstract
oocytes. R299 of hPKD2L1 was revealed to be involved in L-pyroglutamic acid binding in a concentration-dependent manner. As a result, it is possible to objectify the change in signal intensity according to the concentration of L-pyroglutamic acid, an active ingredient involved in the taste of kimchi, at the molecular level. Since the taste of other ingredients can also be measured with the method used in this experiment, it is expected that an objective database of taste can be created.
Topics & Concepts
Pyroglutamic acidStereochemistryChemistryBiologyBiochemistryAmino acidBiochemical Analysis and Sensing TechniquesRNA and protein synthesis mechanismsDiet, Metabolism, and Disease