Rhodium-Catalyzed Azine-Directed C–H Amidation with <i>N</i>-Methoxyamides
Tao Ban, Huu-Manh Vu, Jing Zhang, Jia-Yuan Yong, Qiong Liu, Xuqin Li
Abstract
-methoxyamide reagents as an amide source, C-H amidation was realized at the ortho position of azine under the action of rhodium and boric acid. The method has mild reaction conditions, high atomic utilization, excellent yield, and wide adaptability to amidation reagents (both aromatic amides and fatty amides are applicable). Amide-substituted ketones can be obtained by a simple treatment and can be further transformed into bioactive substances. This provides a good supplement for the C-H bond amidation of aromatic rings.
Topics & Concepts
ChemistryAzineRhodiumAmideReagentCatalysisYield (engineering)Combinatorial chemistryBoric acidOrganic chemistryThioamideMedicinal chemistryMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis