Pathological response following neoadjuvant immunotherapy in mismatch repair-deficient/microsatellite instability-high locally advanced, non-metastatic colorectal cancer
Anai N. Kothari, Michael G. White, Oliver Peacock, Harmeet Kaur, Sarah Palmquist, Nancy You, Melissa W. Taggart, Usama Salem, Michael J. Overman, Scott Kopetz, George J. Chang
Abstract
This case series demonstrates an excellent pathological response to neoadjuvant checkpoint inhibitor (CPI) therapy in patients with mismatch repair-deficient (dMMR) colorectal cancer, which has translated into exemplary short-term oncological outcomes. As well as validating the utility of neoadjuvant CPI therapy in dMMR colorectal cancer, it also opens the door to future study of limited resection in patients with tumours that would otherwise require multivisceral resection.
Topics & Concepts
MedicineMicrosatellite instabilityColorectal cancerPathologicalNeoadjuvant therapyOncologyDNA mismatch repairImmunotherapyComplete responseInternal medicineCancerChemotherapyMicrosatelliteBreast cancerBiochemistryChemistryAlleleGeneGenetic factors in colorectal cancerColorectal Cancer Treatments and StudiesCancer Immunotherapy and Biomarkers