Defluorinative phosphorylation of perfluoroalkyl ketones: synthesis of fluoroalkylated and phosphorylated furan derivatives
Qing‐Dong Wang, Chen Zhang, Li-Wen Sun, Xin-Long Luo, Weidong Rao, Zhi‐Liang Shen, Xue‐Qiang Chu
Abstract
An efficient method for the synthesis of fluoroalkylated tri(hetero)arylphosphine oxides from polyfluoroalkyl ketones and phosphine oxides or phosphonates has been developed.
Topics & Concepts
ChemistryPhosphineFuranPhosphorylationOrganic chemistryCombinatorial chemistryMedicinal chemistryBiochemistryCatalysisFluorine in Organic ChemistryOrganophosphorus compounds synthesisCyclopropane Reaction Mechanisms