The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited
Leandro Fernández-García, Jenniffer Angulo, Hade Ramos, Aldo Barrera, Karla Pino, Jorge Vera‐Otarola, Marcelo López‐Lastra
Abstract
Dengue virus (DENV), the etiological agent of dengue, a febrile and hemorrhagic disease, infects millions of people per year in tropical and subtropical countries. When infecting cells, DENV induces stress conditions known to inhibit canonical protein synthesis.
Topics & Concepts
Internal ribosome entry siteBiologyEIF4GDengue virusVirologyTranslation (biology)Messenger RNAProtein biosynthesisEukaryotic translationVirusMolecular biologyGeneticsGeneMosquito-borne diseases and controlViral Infections and Immunology ResearchPlant Virus Research Studies