Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis
Chunye Zhang, Ming Yang
Abstract
BACKGROUND: Liver cancer ranks the third cause of cancer-related death worldwide. The most common type of liver cancer is hepatocellular carcinoma (HCC). The survival time for HCC patients is very limited by years due to the lack of efficient treatment, failure of early diagnosis, and poor prognosis. Ubiquitination plays an essential role in the biochemical processes of a variety of cellular functions. AIM: To investigate three ubiquitination-associated genes in HCC. METHODS: gene expression level with cancer stage, prognostic outcome, and TP53 mutant status was studied. RESULTS: genes, indicating an association between UBE2 expression with p53 function. CONCLUSION: In summary, this study shed light on the potential roles of UBE2C, UBE2T, UBE2S on diagnostic and prognostic biomarkers for HCC. Moreover, based on our findings, it is appealing to further explore the correlation of those genes with TP53 mutation in HCC and the related mechanisms.