Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer
Preethi Korangath, James D. Barnett, Anirudh Sharma, Elizabeth Henderson, Jacqueline Stewart, Shu-Han Yu, Sri Kamal Kandala, Chun-Ting Yang, Julia S. Caserto, Mohammad Hedayati, Todd D. Armstrong, Elizabeth M. Jaffee, Cordula Gruettner, Xian Zhou, Wei Fu, Chen Hu, Saraswati Sukumar, Brian W. Simons, Robert Ivkov
Abstract
T cell infiltration and tumor growth delay that was independent of antibody therapeutic activity. These results suggest that antitumor immune responses can be induced by systemic exposure to nanoparticles without requiring a therapeutic payload. We conclude that immune status of the host and microenvironment of solid tumors are critical variables for studies in cancer nanomedicine and that nanoparticle technology may harbor potential for cancer immunotherapy.