How does ferrocene correlate with ferroptosis? Multiple approaches to explore ferrocene-appended GPX4 inhibitors as anticancer agents
Wei Li, Jing Yu, Jing Wang, Xuejing Fan, Ximing Xu, Hui Wang, Ying Xiong, Xinyu Li, Xiaomin Zhang, Qianer Zhang, Xin Qi, Pascal Pigeon, Qing Gu, Julia Bruno-Colmenárez, Gérard Jaouen, Michael J. McGlinchey, Xue Qiu, Shu‐Li You, Jing Li, Yong Wang
Abstract
rational design may not only advance the development of ferroptosis-based anticancer treatment, but also illuminate the multiple roles of the ferrocenyl component, thus opening the way to novel bioorganometallics for potential disease therapies.
Topics & Concepts
FerroceneCombinatorial chemistryChemistryStereochemistryPharmacologyComputational biologyBiologyPhysical chemistryElectrodeElectrochemistryFerrocene Chemistry and ApplicationsTrace Elements in HealthDrug Transport and Resistance Mechanisms