Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogens

Abstract

. We highlight how these studies confirm previously identified mechanisms and, importantly, reveal novel ones. We also discuss the challenges for model advancement, including platform engineering to integrate environmental conditions, innate immune cells and the resident microbiome, and the potential for pre-clinical testing of recently developed antimicrobial drugs and vaccines.

Topics & Concepts