Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma
Jiaomeng Pan, Mao Zhang, Liangqing Dong, Shuyi Ji, Juan Zhang, Shu Zhang, Youpei Lin, Xiaoying Wang, Zhen‐Bin Ding, Shuang–Jian Qiu, Daming Gao, Jian Zhou, Jia Fan, Qiang Gao
Abstract
ABBREVIATIONS: cld-CASP3: cleaved caspase 3; cld-PARP: cleaved PARP; DTP: drug tolerant persister; GO: Gene Ontology; GTEx: The Genotype-Tissue Expression; HCC: hepatocellular carcinoma; HCQ: hydroxychloroquine; IC50: half maximal inhibitory concentration value; KEGG: Kyoto Encyclopedia of Genes and Genomes; LAPTM5: lysosomal protein transmembrane 5; NT: non-targeting; PDC: patient-derived primary cell lines; PDO: patient-derived primary organoid; TCGA: The Cancer Genome Atlas.
Topics & Concepts
BiologyKEGGHepatocellular carcinomaCRISPRGeneCancer researchGenomeGeneticsMolecular biologyGene expressionGene ontologyRNA modifications and cancerCancer Genomics and DiagnosticsCancer Mechanisms and Therapy