TSTA3 facilitates esophageal squamous cell carcinoma progression through regulating fucosylation of LAMP2 and ERBB2
Ling Zhang, Yingzhen Gao, Xiaojuan Zhang, Min Guo, Jie Yang, Heyang Cui, Pengzhou Kong, Xia Niu, Yanghui Bi, Jing Xu, Ting Yan, Yanchun Ma, Jian Yang, Yu Qian, Fang Wang, Hongyi Li, Feng Liu, Xiaolong Cheng, Yongping Cui
Abstract
Our results indicate that TSTA3 may be a driver of ESCC metastasis through regulating fucosylation of LAMP2 and ERBB2. Fucosylation inhibitor may have prospect to suppress ESCC metastasis by blocking aberrant fucosylation.
Topics & Concepts
FucosylationEsophageal squamous cell carcinomaBasal cellCancer researchCellCarcinomaChemistryMedicineInternal medicineGlycoproteinBiochemistryGlycanGlycosylation and Glycoproteins ResearchRNA modifications and cancerUbiquitin and proteasome pathways