K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>/I<sub>2</sub>-Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[<i>b</i>]azepines
Zhen Zhang, Shilong Wang, Pengpeng Tan, Xiao‐Wen Gu, Wenjie Sun, Chang Liu, Jinchun Chen, Jiazhu Li, Kai Sun
Abstract
A novel and simple organoselenium-involved 7-membered cyclization to access diverse seleno-benzo[b]azepines has been developed. This protocol involves an electrophilic cyclization process and is accomplished under mild conditions. Discussion of the mechanism rationalizes the regioselectivity observed in transformation. The studies of further transformation of seleno-benzo[b]azepines and large-scale experiment reveal the promising utility of this methodology.
Topics & Concepts
ElectrophileChemistryRegioselectivityTransformation (genetics)StereochemistryCombinatorial chemistryOrganic chemistryCatalysisBiochemistryGeneOrganoselenium and organotellurium chemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods