Lymph-Node-Based CD3 <sup>+</sup> CD20 <sup>+</sup> Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection
Sadia Samer, Ankita Chowdhury, Tomas Raul Wiche Salinas, Perla M. Del Río Estrada, Morgan A. Reuter, Gregory K. Tharp, Steven E. Bosinger, Barbara Cervasi, James Auger, Kiran Gill, Yuria Ablanedo‐Terrazas, Gustavo Reyes‐Terán, Jacob D. Estes, Michael R. Betts, Guido Silvestri, Mirko Paiardini
Abstract
The HIV reservoir is largely composed of latently infected memory CD4 + T cells that persist during antiretroviral therapy and constitute a major barrier toward HIV eradication. In particular, CD4 + T follicular helper cells have been demonstrated as key targets for viral replication and persistence under ART.
Topics & Concepts
BiologyVirologyLymph nodeViral replicationLymphImmunologyInterleukin 21Simian immunodeficiency virusCD8Cytotoxic T cellVirusImmune systemGeneticsMedicinePathologyIn vitroHIV Research and TreatmentImmune Cell Function and InteractionCytomegalovirus and herpesvirus research