Access to Axially and Centrally Chiral Sulfinamides via Asymmetric Allylic Alkylation
Gaoliang Zheng, Xin Li, Jin‐Pei Cheng
Abstract
Herein, access to axially and centrally chiral sulfinamides via asymmetric allylic alkylation was reported. A series of sulfinamides were obtained with good outcomes (up to 99% yield, >19:1 dr, and 98:2 er). The synthetic utility of the reaction was demonstrated by scaled-up synthesis, product transformation, and application as a catalyst in asymmetric catalysis.
Topics & Concepts
Tsuji–Trost reactionChemistryYield (engineering)AlkylationAllylic rearrangementAxial symmetryCatalysisCombinatorial chemistryOrganic chemistryMaterials scienceMathematicsGeometryMetallurgyAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloidsAsymmetric Synthesis and Catalysis