Alkyne/thio umpolung tactic replacement: synthesis of alkynyl sulfides <i>via</i> capturing the <i>in situ</i> formed alkynylthiolate anion
Donghui Xing, Mengxia Feng, Yuzhen Zheng, Bin Huang, Huanfeng Jiang, Liangbin Huang
Abstract
We have developed a general and easily accessible alkynylthio nucleophile precursor to couple with various accessible carbon electrophiles, as an attractive route for their synthesis.
Topics & Concepts
UmpolungChemistryElectrophileNucleophileThio-In situAlkyneCombinatorial chemistryIonMedicinal chemistryOrganic chemistryCatalysisSulfur-Based Synthesis TechniquesClick Chemistry and ApplicationsCatalytic Alkyne Reactions