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TRIM21 drives intervertebral disc degeneration induced by oxidative stress via mediating HIF-1α degradation

Jiancheng Zheng, Leilei Chang, Xiaogang Bao, Xingkai Zhang, Changwei Li, Lianfu Deng

2021Biochemical and Biophysical Research Communications22 citationsDOI

Topics & Concepts

Oxidative stressUbiquitin ligaseDegeneration (medical)UbiquitinOxidative phosphorylationDownregulation and upregulationCell biologyIntervertebral discChemistryBiologyBiochemistryMedicineGeneAnatomyPathologySpine and Intervertebral Disc PathologyPlant Toxicity and Pharmacological PropertiesPain Mechanisms and Treatments
TRIM21 drives intervertebral disc degeneration induced by oxidative stress via mediating HIF-1α degradation | Litcius