Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
Vivek Reddy Palicharla, Sun‐Hee Hwang, Bandarigoda N. Somatilaka, Emilie Legué, Issei S. Shimada, Nicole E. Familiari, Vanna M. Tran, Jeffrey B. Woodruff, Karel F. Liem, Saikat Mukhopadhyay
Abstract
Mechanisms of ciliary transport of ARL13B, a common ciliary protein, by TULP3 are described. An amphipathic helix preceding the ARL13B GTPase domain that couples with the TULP3 tubby domain for ciliary transport is identified. These findings implicate the tubby domain in capturing helical secondary structural motifs from cargoes.
Topics & Concepts
BiologyCiliumIntraflagellar transportDomain (mathematical analysis)Cell biologyHelix (gastropod)GTPaseProtein domainTransport proteinAmphiphileBiochemistryFlagellumGeneChemistryMathematicsPolymerSnailOrganic chemistryCopolymerEcologyMathematical analysisGenetic and Kidney Cyst DiseasesCellular transport and secretionMicrotubule and mitosis dynamics