Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of <i>Candida albicans</i>
Guolei Zhao, Laura N. Rusché
Abstract
We found that loss of Sir2 but not Hst1 or Hst2 hampered hypha formation. Moreover, the defect was caused by the loss of the catalytic activity of Sir2. Our study may lay the groundwork for discovering novel targets for antifungal therapies.
Topics & Concepts
Candida albicansHyphaSirtuinBiologyCell biologyCorpus albicansMutantCytoplasmYeastGeneMicrobiologyGeneticsAcetylationSirtuins and Resveratrol in MedicineAntifungal resistance and susceptibilityCoffee research and impacts