The Lipid Flippases ALA4 and ALA5 Play Critical Roles in Cell Expansion and Plant Growth
James A Davis, Randall B. Pares, Tilde Bernstein, Stephen C. McDowell, Elizabeth Brown, Jason Stubrich, Alexa Rosenberg, Edgar B. Cahoon, Rebecca E. Cahoon, Lisbeth R. Poulsen, Michael Palmgren, Rosa L. López‐Marqués, Jeffrey F. Harper
Abstract
rosettes had perturbations in glycerolipid and sphingolipid content. Assays in yeast revealed that ALA5 can flip a variety of glycerolipids and the sphingolipid sphingomyelin across membranes. These results support a model whereby the flippase activity of ALA4 and ALA5 impacts the homeostasis of both glycerolipids and sphingolipids and is important for cellular expansion during vegetative growth.
Topics & Concepts
Cell biologyBiologyLipid metabolism and biosynthesisPhotosynthetic Processes and MechanismsPlant Molecular Biology Research