PTEN inhibitor attenuates cardiac fibrosis by regulating the M2 macrophage phenotype via the PI3K/AKT/TGF-β/Smad 2/3 signaling pathway
Chenchen Zhuang, Ziyi Guo, Jumo Zhu, Wenjuan Wang, Runmin Sun, Miaomiao Qi, Qiongying Wang, Xin Fan, Runxin Ma, Jing Yu
Topics & Concepts
MedicineProtein kinase BCardiac fibrosisSMADMacrophage polarizationPI3K/AKT/mTOR pathwayPTENFibrosisLY294002Cancer researchTransforming growth factorMacrophageEndocrinologyInternal medicineSignal transductionCell biologyBiologyIn vitroBiochemistryCardiac Fibrosis and RemodelingPeptidase Inhibition and AnalysisCardiac tumors and thrombi