EGR1/NOX4 pathway regulates oxidative stress and further facilitates fibrosis progression in keloids responses to TGF-β1
Haiyan Qin, Lianbo Zhang, Mingxi Li, Ying Liu, Shilong Sun, Wenting Nie, Bing Bai, Gaokai Li, Guang Zhang
Topics & Concepts
KeloidNOX4Transforming growth factorCancer researchSMADEGR1FibrosisFibroblastTransfectionSignal transductionMolecular biologyChemistryNADPH oxidaseBiologyDownregulation and upregulationReactive oxygen speciesCell biologyMedicineCell culturePathologyGeneBiochemistryGeneticsDermatologic Treatments and ResearchFibroblast Growth Factor ResearchWound Healing and Treatments