Tuning alginate β-lactoglobulin complex coacervation by modulating pH and temperature
Mikkel Madsen, Hossein Mohammad‐Beigi, Peter Westh, Finn L. Aachmann, Birte Svensson
Abstract
upon coacervation. Proton release and uptake were quantified at pH 2.65 and 4.00 by isothermal titration calorimetry to be 4 and 2 protons per β-Lg molecule, respectively. By increasing the temperature to 65 °C, we discovered a secondary β-Lg concentration dependent coacervation step, where the formed particles change into large assemblies driven by entropy. These findings bring new insights to complex coacervation and its applicability in microencapsulation and drug delivery.
Topics & Concepts
CoacervateIsothermal titration calorimetryChemistryTitrationChemical engineeringMacromoleculeTurbidimetryBiomoleculePolysaccharideChromatographyInorganic chemistryOrganic chemistryPhysical chemistryBiochemistryEngineeringProteins in Food SystemsMicroencapsulation and Drying ProcessesPolymer Surface Interaction Studies