Electrospinning of ampicillin trihydrate loaded electrospun PLA nanofibers I: effect of polymer concentration and PCL addition on its morphology, drug delivery and mechanical properties
Tuğba Eren Böncü, Nurten Özdemir
Abstract
It was aimed to produce ampicillin trihydrate loaded electrospun PLA and PLA/PCL nanofibers using HFIP as solvent. The effect of PLA concentration (7.5–12.5%), PCL addition and added PCL amount (20–80%) on the nanofibers properties were investigated. The increase in PLA concentration caused an increase in nanofiber diameter and a decrease in mechanical properties. PLA nanofibers have shown biphasic controlled drug release up to 10 days, while PCL nanofiber caused only a rapid burst effect. As a result, PLA concentration and the amount of added PCL affected the average nanofiber diameter, in vitro drug release and mechanical properties of the obtained electrospun nanofibers.
Topics & Concepts
NanofiberElectrospinningMaterials scienceChemical engineeringPolymerDrug deliveryPolymer chemistryComposite materialNanotechnologyEngineeringElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative Medicinebiodegradable polymer synthesis and properties