AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss
Santanu Hati, Marisa Zallocchi, Robert A. Hazlitt, Yuju Li, Sarath Vijayakumar, Jaeki Min, Zoran Ranković, Sándor Lovas, Jian Zuo
Topics & Concepts
ChemistryCyclin-dependent kinase 2OtotoxicityKinaseIn vivoPharmacologySmall moleculeBiochemistryCisplatinProtein kinase ABiologyInternal medicineMedicineChemotherapyBiotechnologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments