Models of sepsis-induced acute kidney injury
Liang Dong, Yiling Xie, Ren-Tao Zhang, Hu Q
Abstract
Sepsis-induced acute kidney injury (S-AKI) is one of the most serious life-threatening complications of sepsis. The pathogenesis of S-AKI is complex and there is no effective specific treatment. Therefore, it is crucial to choose suitable preclinical models that are highly similar to human S-AKI to study the pathogenesis and drug treatment. In this review, we summarized recent advances in the development models of S-AKI, providing reference for the reasonable selection of experimental models as basic research and drug development of S-AKI.
Topics & Concepts
Acute kidney injurySepsisMedicinePathogenesisIntensive care medicineDrugBioinformaticsPharmacologyInternal medicineBiologyAcute Kidney Injury ResearchSepsis Diagnosis and TreatmentChronic Kidney Disease and Diabetes