Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
Arianna Colini Baldeschi, Marco Zattoni, Silvia Vanni, Lea Nikolić, Chiara Ferracin, Giuseppina La Sala, Maria Summa, Rosalia Bertorelli, Sine Mandrup Bertozzi, Gabriele Giachin, Paolo Carloni, María Laura Bolognesi, Marco De Vivo, Giuseppe Legname
Abstract
studies in prion-infected mice, our strategy emerges as a novel and effective approach to the treatment of prion disease.
Topics & Concepts
Prion proteinChemistryDownregulation and upregulationIn vivoDrugDrug discoveryBioavailabilityDrug developmentSmall moleculeIn vitroNeurodegenerationLead compoundVirologyComputational biologyPharmacologyDiseaseBiochemistryBiologyGeneticsGeneMedicinePathologyPrion Diseases and Protein MisfoldingHIV Research and TreatmentTrace Elements in Health