Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis
Juan Wang, Zeyuan Cao, Panpan Wang, Xiao Zhang, Jianxia Tang, Yifan He, Zhiqing Huang, Xueli Mao, Songtao Shi, Xiaoxing Kou
Abstract
. Subsequently, apoEVs use their Fas ligand to activate the Fas pathway in MM cells, leading to the initiation of apoptosis. This study identifies the role of apoEVs in inducing MM apoptosis and suggests a potential for apoEVs to treat MM.
Topics & Concepts
ApoptosisFas ligandCell biologyExtracellularCellCytoplasmIntracellularProgrammed cell deathBiologyMesenchymal stem cellUVB-induced apoptosisFas receptorCancer cellChemistryCaspaseCancerBiochemistryGeneticsExtracellular vesicles in diseasePhagocytosis and Immune RegulationMicroRNA in disease regulation